Experiments on Active Immunization against Experimental Poliomyelitis

The expanded programme in immunization against measles and poliomyelitis, Iran's Experience.

Active Immunization against Poliomyelitis

1. A single intracutaneous inoculation with a subinfective dose of the virus of poliomyelitis produces considerable immunity. 2. Virus-serum combinations produce an appreciable immunity, providing just sufficient serum is used to protect the animal from paralysis. If there is an excess of serum, the degree of immunity is considerably reduced.

Observations on the Immunological Relation of Poliomyelitis to Louping Ill

The results of the work presented in the present paper show that louping ill and poliomyelitis immunologically are not closely related. Although relatively few experiments were performed, the data obtained were sufficiently decisive for our purposes. Certainly nothing was found to indicate that one might be able to immunize human beings against poliomyelitis by the use of louping ill virus. In ...

Active Immunization against Poliomyelitis in Monkeys

1. A combination of poliomyelitis virus and specific human serum is effective for the production of active immunity. 2. For each gram of active virus given intradermally as an emulsion, 6 cc. of human immune serum, injected subcutaneously, was required in our experiments to protect a monkey from paralysis. Some degree of active immunity was induced. 3. Immunity, without symptom of the disease, ...

Intradermal versus Subcutaneous Immunization of Monkeys against Poliomyelitis

1. The introduction of considerable amounts of living, active poliomyelitis virus into the skin and subcutaneous tissue of monkeys protects the animals against intracerebral inoculations of similar virus material. 2. The degree of protection conferred by intradermal is greater than by subcutaneous injection. 3. During intradermal and subcutaneous inoculations, no local or general pathological s...